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In general, these compounds are most desirably administered in effective dosages, depending upon the weight and condition of the subject being treated and the particular route of administration chosen. The alkynyl R 9 group can be substituted with any substituent which allows the tetracycline compound of the invention to perform its intended function.  Aufgrund einer Einigung mit Pfizer wird Teva Sildenafil ab 2017 anbieten.
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